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Mutation in the androgen receptor gene AR; on the X chromosome has been found in cases of male breast cancer see Mutation in the RAD51 gene has been found in patients with familial breast cancer Breast cancer susceptibility alleles have been reported in the CHEK2 gene see Furthermore, the European natural breast enhancers
gene on 17q is commonly amplified in breast cancer and appears to lead to cell transformation by abrogating p53 tumor suppressor activity Bulavin et al. Somatic mutations in the following genes have been identified in breast cancer: